Several drugs are thought to interact with Vitamin B12, and the primary problem with these medications is that they decrease absorption of Vitamin B12.

  PPI’s and H2 receptor antagonists are used to treat gastroesophageal reflux disorders and peptic ulcer disease. PPI’s may interfere with B12 absorption from food because they slow the release of hydrochloric acid into the stomach. (Hydrochloric acid releases B12 from proteins.) Despite this, very little evidence exists to show that these medications will cause a deficiency, even with long-term use.

  PPI stands for proton pump inhibitors.

  Gastroesophageal reflux disorders (GERD) are defined as chronic symptoms or mucosal disorders by abnormal refluxes into the esophagus.

  Peptic ulcer disease is a common ailment and refers to the formation of painful sores in the lining of the stomach caused by an imbalance of digestive fluids in the stomach and duodenum.

  Metamorforin is a drug used to treat diabetes and may interfere with calcium metabolism, which may interfere with B12 absorption because calcium is needed to absorb B12. Although the reduction of B12 may be only slight a user of Metamorforin should discuss with their health care provider the risks of B12 deficiency.

• http://dietary-supplements.info.nih.gov/factsheets/vitaminb12.asp
• http://www.vitacost.com/Healthnotes/Supp/Vitamin-B12.aspx